GHGA is a highly collaborative consortium composed of numerous institutions across Germany.
The German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) operates one of the largest sequencing facilities in continental Europe and has been at the forefront of translating omics technologies to the clinics. Through the National Center of Tumor Diseases, the Hopp Children’s Tumor Center and the German Cancer Consortium, genomes from more than 1,000 cancer patients per year are sequenced with the results routinely feeding into molecular tumor boards. DKFZ will host central components of GHGA and contributes its institutional expertise and scientific networks to establish the GHGA infrastructure.
The Eberhard Karls University Tübingen (EKUT) is one of the leading German research universities and one of the eleven German universities of excellence. EKUT has been centralizing its omics data generation and management with the establishment of the Quantitative Biology Center, a DFG-co-funded core facility.
The University Hospital Tübingen (UKT) is a highly specialized clinical center treating more than 420,000 patients per year. The Institute of Medical Genetics and Applied Genomics (IMGAG) is part of several European Reference Networks (ERNs) for rare diseases, is leading the European Solve-RD consortium, and is one of four German competence centers for Next Generation Sequencing (NGS Competence Center Tübingen, NCCT) funded by the DFG.
Charité is the largest university hospital in Europe, seeing and treating over 900.000 patients per year. The Charité Comprehensive Cancer Center (CCCC) is one of the most active study centers providing the central infrastructure for translational precision oncology programs embedded in the German Consortium for Translational Cancer Research (DKTK). NGS-based molecular diagnostics is integrative part of patient care which is performed under accredited conditions at the Institute of Pathology.
The Max Delbrück Center for Molecular Medicine (MDC) was founded with the goal of understanding the molecular basis of health and disease by bringing together researchers from different disciplines. As an institutional member of the Berlin Institute for Health (BIH), the MDC also drives translational efforts, creating infrastructure, large-scale studies and connections between basic science and clinical research.
University Hospital Heidelberg (UHH) is among the largest and most prestigious medical centers in Europe, treating more than 59,700 patients very year, 40% of these contacts are cancer-related. The National Center for Tumor Diseases (NCT) was founded as an exceptional alliance between DKFZ and UHH together with the Heidelberg Medical Faculty and German Cancer Aid (Deutsche Krebshilfe).
The Heidelberg Academy of Sciences and Humanities (HAdW) is one of eight state academies in Germany. Since its establishment in 1909, the Academy promotes interdisciplinary research through inter-faculty and international inter-university cooperation. It contributes legal and policy expertise in international research associations that work on solutions as well as independent recommendations for politics and society in the area of health-related data processing and sharing, such as internationally the European Open Science Cloud Pilot of the EU Commission (EOSCPilot), the EU-Canada Cancer Network (EUCANCan), and nationally by various regulatory advice on the application of AI in healthcare.
At Kiel University (CAU), omics-based medical life science research is a long-standing focus, which is documented by leading roles in international consortia and publications. Focus areas include inflammation research (DFG Cluster of Excellence Precision Medicine in Chronic Inflammation), microbial genomics, longevity research, cancer and ancient DNA. CAU operates one of four DFG-funded national academic sequencing centers.
NAKO e.V. is the legal entity implementing and owning the data of the German National Cohort (GNC). It is a prospective population-based cohort study, which recruited more than 200,000 men and women in 18 study centers around the country.
The European Molecular Biology Laboratory (EMBL) is Europe’s flagship institution for molecular biology and biodata, with the EMBL-European Bioinformatics Institute (EMBL-EBI), a subsidiary of EMBL, hosting and operation the EGA (European Genome Archive). These direct links, together with the agreement of EMBL-EBI to provide code and support to GHGA, will secure the necessary expertise for transferring technology from the EGA to our consortium.
Leibniz Supercomputing Centre (LRZ) supports ground-breaking research and education throughout a wide range of scientific disciplines by offering highly available, secure and energy-efficient services based on cutting-edge IT technology. Today it is one of the foremost European computing centres in the area of scientific research by academic communities.
The Helmholtz Centre for Infection Research (HZI) is Germany’s largest academic institution dedicated exclusively to infection research. In line with its mission, the centre develops new strategies for the early detection, prevention, and treatment of infectious diseases. HZI researchers investigate bacterial and viral pathogens of high clinical relevance, elucidate their interactions with the host‘s immune system and explore new ways to prevent and combat infections.